The hypothesis is that casein phosphopeptide stabilized amorphous calcium phosphate fluoride releasing (CPP-ACP-NaF) dental varnish will be more effective at reducing enamel demineralization than the control varnish base that does not contain CPP-ACP-NaF.
Child to Adult
Research participants will be between 10 and 80 years of age who are subjects undergoing orthodontic treatment at the Department of Orthodontics Clinic, School of Dental Medicine, University of Colorado.
Detailed Eligibility: The following inclusion criteria will be applied: comprehensive fixed orthodontic treatment with brackets from at least second premolar to second premolar, treatment planned already for the extraction of at least 2 bicuspids (any combination), patient at the University of Colorado School of Dental Medicine Orthodontic Clinic, can place bracket base on teeth to be extracted for at least 1 month prior to extractions, no previous white spot lesions, caries or restorations present on the facial surface of the teeth being studied, adequate oral hygiene, not allergic to milk products.
I - Research Studies that focus on the safety of a drug. The goal is to determine the drug's most frequent and serious adverse events and, often, how the drug is broken down and excreted by the body. These studies usually involve a small number of participants.
UCD Dental Clinic
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