The purpose of this research study is to use MRI to understand how skeletal muscles and blood vessels respond to exercise in people with and without Type 2 Diabetes
To study a new anti-obesity medication
Compare the change in 24-h EE in response to acute fasting in pre- and postmenopausal women. Compare the change in 24-h EE in pre- and postmenopausal women in response to acute low-protein overfeeding (200% of energy balance).
A Phase 2, Randomized, Human Growth Hormone-Controlled, Multicenter, Basket Study of Vosoritide in Children with Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome with an Inadequate Response to Human Growth Hormone
Are you a woman taking non-hormonal therapy for hot flashes or night sweats? We want to learn how this affects your sleep, daily life, and work.
The primary objectives of DISCOVERY are to: 1. Identify the physiologic drivers and other determinants of progression to youth-onset T2D by charting the course of changes in glycemia, β-cell function, insulin sensitivity, psychosocial, behavioral, and social determinants of health during this critical period of maturation 2. Inform approaches for precise prediction of which youth are at h...
This study wants to learn if retatrutide works better than a placebo at lowering the risk of serious heart problems and slowing kidney damage in people with body mass index of 27 or higher.
Can ADAP assay accurately detect GADA, IA2A, IAA and ZnT8A in self-collected capillary dried blood spot specimens.
Join a weight loss research study for men and women aged 18-65 with breast cancer. Receive a free 6-month diet and exercise program and monetary compensation.
The objective of this study is to learn more about normal blood sugars in healthy children without chronic disease.
This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.
The goals of this study are to refine the implementation and pilot test the feasibility of an adapted cognitive behavioral therapy (CBT), the Balanced and Empowered EaTing in Diabetes (or the BEET Diabetes Program), compared with the original CBT program, delivered by behavioral health providers to treat disordered eating behaviors (DEBs) in patients with type 2 diabetes in real-world clinical set...
The purpose of this research study is to examine and understand the various mechanisms that contribute to CFRD and gain a better understanding of possible ways to treat CFRD.
To demonstrate the efficacy of different doses of frexalimab in comparison with placebo and in addition to standard of care (SOC) on endogenous insulin secretion in participants (12-21 y.o.) with newly diagnosed T1D over a 52-week period
To investigate long-term safety of Sogroya (somapacitan) therapy in patients with AGHD in the setting of routine clinical practice with special focus on neoplasms and diabetes mellitus type 2.
The primary outcome variables will be the change in hemoglobin A1c, and diabetes medications recorded at 4.5 month and 13.5 month follow-up assessments.
To evaluate the effect of three doses of Diamyd compared to placebo in terms of (1) beta cell function; and (2) glycemic control in adolescents and adults recently diagnosed with type 1 diabetes (T1D), who carry the human leukocyte antigen (HLA) DR3-DQ2 haplotype and have antibodies against GAD65.
This study wants to learn how losing weight affects cell communication in muscle fat tissue among people with obesity. We also want to see how this impacts insulin resistance, inflammation, and muscle strength.
• Examine the clinical efficacy of 1000 mg/m2 /day of oral DFMO to stabilize or improve loss of β cell function in persons with recent onset T1D. Our primary endpoint defining clinical efficacy will be based on mixed-meal stimulated C-peptide AUC in the treatment group compared to placebo after 6 months of DFMO treatment. • Examine the safety and tolerability of 1000 mg/m2 /d...
This study wants to learn more about how exposures during pregnancy like infections, diet and growth, can affect a baby’s chances of developing type 1 diabetes later in life.
This study will collect data from health records about people that have variations in their X & Y chromosomes to learn about their health. We also ask if people are willing to join future studies about X & Y variations.
We are recruiting people with and without type 2 diabetes (T2D), aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.
This study is looking for male and female participants with prediabetes that are aged 18 to 45 years old to learn how how short, frequent periods of physical activity impact your health.
The purpose of this study is to understand the role of semaglutide, with or without metformin, in restoring ovulation in youth and adults (12-35 years old) with polycystic ovary syndrome.
This study plans to learn more about how different adipose tissues are related to diabetes and muscle mass and strength, as well as how to non-invasively track liver disease in those undergoing elective abdominal surgeries.
The primary objective of this study is to evaluate the efficacy of subtypeselective Janus kinase (JAK) inhibitors in the preservation of β cell function in participants with recent onset Stage 3 T1D (diagnosed within 100 days)
Determine if copeptin levels, a marker of vasopressin, correlates with presence and severity of fatty liver disease.
The purpose of this study is to learn more about the effects of an investigational drug called semaglutide as a safe and effective means of improving cardiovascular function, kidney function, and insulin sensitivity in adults with type 1 diabetes.
The goal of this study is to see how when you eat and when you exercise (morning or evening) affects metabolism.
This study wants to learn more about the best times of day to eat that lead to weight loss for adults with overweight or obesity.
The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight
