Do you currently smoke? Would you like to know if you are one of the 4 in 10 people who may develop COPD someday?
1. Determine if L-citrulline supplementation improves asthma control and increases FeNO (co-primary outcomes). Secondary outcomes will include changes in plasma L-arginine/ADMA, lung function (FEV1) and bronchial hyperreactivity. Asthmatic subjects will receive either 15 g L-citrulline/day or matched placebo for 7 weeks followed by a 4 week washout and then 7 weeks of the opposite treatment. A pa...
1. Determine if L-citrulline supplementation improves deployment related asthma control and increases FeNO (co-primary outcomes). Subjects will receive either 15 g L-citrulline/day or matched placebo for 7 weeks followed by a 4-6 week washout and then 7 weeks of the opposite treatment.
This study is being done to learn more about sweat electrolytes in people who do not have Cystic Fibrosis to inform goals for CF treatment.
Primary objective: To assess the persistence rate of patients undergoing pulmonary arteriovenous malformation (PAVM) embolization at multiple hereditary hemorrhagic telangiectasias (HHT) centers of excellence in the United States using standardized reports. Second objective: To assess the impact of technical factors like the type of embolic device and embolization technique (feeding artery vs. ve...
Investigators at the University of Colorado are conducting research on the ability to exercise under high altitude (low oxygen) conditions. The study is looking at the safety and effects on exercise of a high dose of an inhaled asthma medication (salmeterol/fluticasone, or Advair®) on exercise performance while breathing low-oxygen air.
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response to pulmonary hypertension (high pressure in the lungs) during rest and exercise. By identifying patterns of right ventricular dysfunction, this study will help identify bette...
In this study, we plan to learn about the causes of rheumatoid arthritis (RA) and about lung disease in RA. RA is an autoimmune disease that can cause arthritis, and in some people, RA can also be related to lung disease called ‘interstitial lung disease’ (or ILD).
This study will investigate the maximum tolerated dose, the recommended dose for expansion (RDE), safety, efficacy, and pharmacokinetics of MK-6070 alone, MK-6070 with Atezolizumab and MK-6070 with I-DXd in participants with advanced cancers associated with expression of Delta-like Canonical Notch Ligand 3 (DLL3)
The Lung PCA BU goals include enrollment of informative retrospective and prospective patients from which informative biospecimens can be collected and processed for advanced analyses of PMLs. Central to this process will be the development of techniques to optimize data production from limited tissues. The generation of a deep and interactive database will be critical to help direct the studies...
This study plans to learn more about pulmonary fibrosis and determine if some diseases that cause scarring in the lung might be inherited diseases. We are especially interested in the genetics of pulmonary fibrosis and cases where it might run in families. What we learn may be helpful in the future to people with pulmonary fibrosis and their family members.
To determine if the chronic administration of riociguat improves exercise hemodynamic profiles measured by tight heart catheterization (RHC) - in patients with subjective exercise limitation at least 6 months post-PTE surgery.
We are looking for people aged 25 to 55 who drink alcohol heavily, and people aged 25 to 55 who never or rarely drink alcohol, to see how alcohol use affects lung health over time.
