To assess the real-world use and effectiveness of belimumab in routine practice for the treatment of adults with active lupus nephritis. Aims to provide the first long-term assessment of renal function preservation in patients treated with belimumab.
To evaluate the ability of ravulizumab to reduce proteinuria in adults with IgAN
Evaluate safety and tolerability of SC291; and, to evaluate clinical response to SC291.
Establish the long-term safety and efficacy of pegcetacoplan in participants with C3 glomerulopathy (C3G) or immune complex membranoproliferative glomerulonephritis (IC-MPGN)
To compare whether de novo use of belatacept and sirolimus versus tacrolimus and MMF maintenance therapy will prevent the development of DSA or maintain optimal graft function (eGFR).
To demonstrate the superiority of iptacopan compared to placebo in reducing proteinuria at 6 months of treatment
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response to pulmonary hypertension (high pressure in the lungs) during rest and exercise. By identifying patterns of right ventricular dysfunction, this study will help identify bette...
To test a new medication (BION-1301) for the treatment of IgAN.
This study is looking at the short-term effect of equol supplementation (1, 2, and 3 hours after ingestion) on blood vessel function in women with and without chronic kidney disease. Equol is a dietary supplement. Equol is a metabolite of soy that is produced by the gut microbiome.
To assess the safety and tolerability of ferric citrate in pediatric subjects with hyperphosphatemia related to chronic kidney disease (CKD).
To learn more about the diseases that cause nephrotic syndrome so that improved treatments can be developed.
To evaluate the efficacy of VIB4920 antoagonism of CD40L in achieving a complete renal response in active lupus nephritis
This study plans to test whether oral acetate supplementation is effective at improving artery function and stiffness in healthy adults over 50 years of age.
Finerenone vs. Placebo in addition to Standard of Care on the Progression of Kidney Disease in non-Diabetic Patients
This study plans to learn more about the effects of having too much acid in the blood as a result of having a kidney transplant. This study will look at how acid levels in the blood affect the function of blood vessels and the transplanted kidney.
The objective for this study is to evaluate the effect of crovalimab on treatment-naive patients based on complete response to treatment based on lab measurements
We will recruit 50 adult patients with stage IIIb-IV Chronic Kidney Disease (eGFR 15-45 mL/min/1.73 m2) with clonal hematopoiesis (CH) and 50 adult patients with stage IIIb-IV CKD without CH. All patients will undergo MRI scanning of the upper leg and lower back for assessment of fat in the bone marrow and we will compare the results between the two groups to see if CH is associated with greater b...
The purpose of this study is to learn more about the effects of how many hours a day we eat in adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese and how feasible it is to restrict eating to 8 hours a day.
We are purposing this retrospective and prospective, multicenter observational study in order to facilitate quality improvement and description of treatment with this novel dialysis device dedicated to the treatment of infants with AKI or fluid overload.
To establish whether or not nicotinamide riboside will improve large artery stiffness in patients with stage III and IV chronic kidney disease.
To determine if the chronic administration of riociguat improves exercise hemodynamic profiles measured by tight heart catheterization (RHC) - in patients with subjective exercise limitation at least 6 months post-PTE surgery.
To test CAR T cell therapy (a type of therapy made from one's own immune cells) for refractory lupus nephritis
Develop a database of subjects with inflammatory renal disease. Develop a data and biobank containing securely stored data, blood, urine, stool, endothelial cell samples, and kidney biopsy tissue.
Physical activity and sedentary time will be measured via accelerometry (ActiGraph wGT3X-BT) for 7 days in patients with ADPKD and healthy controls.
