This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back.
This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE.
This study is looking at a medicine called Upadacitinib to see if it is safe and helps adults with moderate to severe lupus (SLE). We want to compare it to a placebo (a pill with no medicine) to see how well it works. We also want to find out how much of the medicine is needed to keep symptoms from getting worse.
In this study we want to learn more about the effects of the study drug, benralizumab, for treating children with eosinophilic granulomatosis with polyangiitis (EGPA).
This study will test if adding a new medicine called VIB4920 to regular lupus treatment can help people with lupus nephritis (a kidney problem caused by lupus) feel better. It will also check if this new medicine is safe.
Researchers are testing a drug called IMVT-1402 to see if it is safe and if it helps people with skin lupus (a type called subacute or chronic cutaneous lupus) with or without lupus that affects the whole body.
We are doing this study to see if a medicine called anifrolumab is safe to use in adults with systemic sclerosis. We also want to find out if the medicine helps with disease symptoms and if it stops the disease from getting worse.
This study will look at how well an injectable treatment works for people with detectable levels of HIV who are taking oral antiretroviral therapy (ART). This study will also check if the treatment is safe, how long it lasts, and ask about people’s experience.
We want to find out how well the medicine Belimumab works in real life for adults who have active lupus nephritis. This study also wants to see if belimumab helps keep the kidneys healthy for a long time.
We are looking for adults to join a national study to help us learn more about how rheumatoid arthritis (RA) develops.
This study is testing a new drug called SC291 to see if it is safe and if it can help treat serious autoimmune diseases that have come back or stopped responding to treatment.
This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints.
To evaluate the efficacy of GS-5718 versus placebo-to-match (PTM) in reducing skin disease activity for participants with CLE with or without systemic lupus erythematosus. To evaluate the efficacy of GS-5718 versus PTM in reducing skin disease activity for participants with CLE with or without SLE. To evaluate the safety and tolerability of GS-5178 in participants with CLE with or without SLE.
This study wants to see if gut problems are worse in HIV+ men that have sex with men that have metabolic syndrome compared those without metabolic syndrome.
This study involves chimeric antigen receptor (CAR) T cell therapy, which is a relatively new therapeutic approach that uses a patient's own immune cells to treat their disease. In autoimmune diseases such as rheumatoid arthritis (RA), certain parts of the immune system are overactive, leading to inflammation. A subtype of immune cells, called regulatory T cells (Tregs), normally help to reduce ...
The primary objective of the current study is to validate the performance of the current ASAS classification criteria in a prospective, combined cohort of patients presenting with undiagnosed current back pain.
The primary objective of this study is to demonstrate efficacy of BIIB059 compared with placebo in participants with active systemic lupus erythematosus (SLE), who are receiving background lupus standard of care (SOC) therapy in reducing disease activity.
To find out if bNAbs, VRC07-523LS and PGT121.414.LS, are safe for administration with ART. To evaluate if the bNAbs are effective at keeping HIV from reproducing. It is necessary to stop taking ART after receiving the bNAbs or placebos for bNAbs. This is referred to as an ATI (analytical treatment interruption).
To longitudinally study individuals at risk for spondyloarthritis and spondyloarthritis associated diseases.
The purpose of this study is to determine how the body's immune system interacts with nuts and other foods to cause allergic reaction. This study also plans to validate a test that is being developed to help predict reactions to peanuts.
Primary objective is to evaluate the effectiveness of cenerimod 4mg at reducing disease activity compared to placebo. The secondary objective is to evaluate the effect of cenerimod 4mg to control the disease compared to placebo. The safety objective is to evaluate the safety and tolerability of cenerimod 4mg.