How When you Eat and Exercise Affect Metabolism in Adults

Primary Objective

The goal of this study is to see how when you eat and when you exercise (morning or evening) affects metabolism.

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As a participant in this study, you will be assigned to 4 different diet and exercise groups where the time of your meals and when you exercise will be different. This will last for 4 consecutive days, and you will be provided meals on 2-3 of the days. On the 5th day of each exercise and diet group, you will complete an exercise test. After you complete each diet and exercise group, you will wait 2-4 weeks before beginning the next diet and exercise group..

Main Procedures Involved: You will be asked to complete 4 consecutive days of exercise for about 5 months. The exercise sessions will be 45-minutes of supervised, moderate intensity aerobic exercise completed on a treadmill at the Anschutz Health and Wellness Center Fitness Center. The exercise test completed on the 5th day of each diet and exercise group will also be completed on a treadmill and will last for 45-minutes and will be followed by a 2-hour test to measure your metabolic rate. You will be asked to wear a heart rate during the exercise sessions that will link to a mobile application on your phone. You will need to bring your phone and heart rate monitor to all exercise sessions, including the exercise test. You will also be asked to wear other devices that will measure your sleep, activity, and blood sugar during each diet and exercise group. A small group of participants will be asked to complete a 6th day during each diet and exercise group that will include a 24-hour stay in a special inpatient hospital room on the Anschutz Medical Campus called a Whole Room Indirect Calorimeter. You will be provided with meals, you will be asked to complete a 45-minute exercise session, and you will be asked to wear physical activity and sleep monitors during this stay.

Duration of Participation: Your total study participation will last up to 6 months.


18 to 40 years


We are recruiting individuals that are aged 18-40 years old that have a BMI between 18.5 and 40 kg/m2 with no acute or chronic disease (cardiovascular disease (CVD), diabetes, pulmonary, gastrointestinal disorders, and orthopedic problems in particular), no contraindication to exercise or physical activity limitations, willing not to enroll in any other formal weight loss or physical activity programs over the next 6 months, are non-smokers, and live or work within 30 minutes of the CU Anschutz Medical Campus... To enroll all participants must meet specific criteria. The criteria listed above is only a partial list of all the requirements to participate in this research study. Only a clinical research staff member can determine eligibility.


CTRC Inpatient

Principal Investigator
Photograph of Seth Creasy

Seth Creasy

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