Use of accelerometer and gyroscope data to improve precision of estimates of physical activity type and energy expenditure in free-living adults

Primary Objective

Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movement the person does. This is done with equations that use the data collected by the activity monitors. There is a critical need for more accurate and precise methods to classify physical type and estimate energy expenditure at the individual level as we move towards using physical activity as a marker in individual health records and tracking changes in health outcomes during clinical and behavioral trials. We would like to test classifications of energy expenditure and physical activity in free living adults, or adults undergoing their normal daily activities in their natural environment.

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Main Procedures Involved: Screening and baseline visit (Approximately 2 hours): During the initial visit, called the screening visit, you will -Review the consent form with a member of the research team. -Complete a medical history form. -Have a physical examination with the study doctor. If you consent and are approved by the doctor for participation, we will then measure your body composition (i.e., how much fat and muscle you have) using a dual x-ray absorptiometry (DXA). You will be asked to lie on a table and the DXA scanner will scan over your body. The procedure lasts about 15 minutes. Study visit (12 hours); You will be asked to stay in the metabolic room (calorimeter) which is located in the Clinical Translational Research Center (CTRC) on the 12th floor of the Anschutz Inpatient Pavilion at the University of Colorado Hospital. The metabolic room is sealed, but fresh air is constantly drawn in. The room is 12 feet by 12 feet and contains a regular hospital bed, a desk, a toilet, a telephone, a flat screen TV with a DVD player, and a computer with internet access. The TV has basic cable TV access (i.e. news and sports channels, some entertainment channels). The room also has wireless internet access, so you can bring your own laptop. There are curtains over the windows so that you may have privacy. The room is also equipped with a closed-circuit camera that can be viewed in the control room and at the nursing station. However, the control for the camera is located inside the room, and you can turn the camera off anytime you want privacy, for example, when going to the bathroom. Temperature inside the calorimeter will be maintained at approximately 72°F (22°C). Prior to entering the room, we will secure the activity monitors to your hip, wrist, and ankle using an elastic belt and Velcro straps. You will enter the room at 8:00 AM, and exit the room at 8:00 PM. You will be served breakfast and lunch at approximately 9:00 AM and 1:00PM. We can also provide a boxed snack for you to take with you after you exit the room. You will order your meals through the Hospital Room Service. You can also drink water and other beverages at any time of the day. During the calorimeter stay, you will be asked to complete a variety of different exercises and activities. You can do these activities and exercise whenever you want and for how long you want We will provide you a check list to follow to be sure that you do all of the prescribed activities. During the stay in the room calorimeter, we will video record you during the day so we have a record of when you did the different activities. The video recordings will be stored and sent for analysis at the University of Tennessee Knoxville. If you leave the room calorimeter early, your participation in this research study will end.



Study ID

Protocol Number: 22-0743

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