Back to Results

The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis

Primary Objective

To evaluate the relationship between the colonic microbiome and the immune system in AS, IBD, AS+IBD, and healthy controls.

Study category: Bones, Muscles, and Joints

Is this Study for You?

Let's Get Started!

Description

This study uses colonic biopsies to compare immune cell function and gut microbiome between those with IBD, AS, AS/IBD overlap, and healthy controls.

Details
Age

Adult

Eligibility

A diagnosis of AS, IBD, or both. Healthy controls are recruited from the existing colonoscopy schedule and have no inflammatory disease present.

Detailed Eligibility: Inclusions: Ages of 18-70. Established AS, IBD, or both for inclusion into disease groups. Exclusions: Pregnancy, use of antibiotics within the past 14 days, current diagnosis of colon cancer, celiac disease, or any other rheumatologic disease.. Chemotherapy or radiation for any malignancy in the past year. Daily use of aspirin or NSAIDs with inability to hold the drug 7 days before and after the procedure. Current use of anticoagulation (LMWH, warfarin, etc.). A diagnosis of HIV. Clostridium dificile within thee past 3 months.

Phase

Pilot - A pilot Study is used to obtain information, and work out the logistics and management, deemed necessary for further Research Studies.

Type of Study

Observational

Scope

Local

Locations

Colorado Research Center
Denver Health Medical Center
University of Colorado Hospital

Principal Investigator
Kristine Kuhn,  MD, PhD

Kristine Kuhn, MD, PhD

Study ID

Protocol Number: 14-1507

More information available at ClinicalTrials.gov: NCT02389075

Is this Study for You?

Let's Get Started!

Not finding the right Study for you? Join ResearchMatch, a nation-wide registry connecting volunteers and researchers