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Nicotinic agonist effects on BMI and neuronal response in overweight/obese adults

Primary Objective

This research study plans to examine the effects of an investigational new drug on neuronal, physiological, and behavioral mechanisms of obesity in the general population.

Study category: Nutrition and Metabolism

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This study plans to learn more about the effects of an investigational new drug (DMXB-A) and its effects on obesity. The study drug has similar effects to nicotine. Since nicotine has been found to effect appetite, we are interested in studying the effects of the study drug, which has similarities to nicotine, on how your brain responds to such things as pictures of food. This study drug has not been approved by the Food and Drug Administration (FDA), and is considered experimental.




BMI greater than 27; Be 21-65 years old; Have no known cardiovascular disease; Be a non-smoker; Not be pregnant or trying to conceive; Be able to complete an MRI scan.

Type of Study

Basic Science


Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Jason Tregellas,  PhD

Jason Tregellas, PhD

Study ID

Protocol Number: 15-0650

More information available at NCT02458313

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